Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus
Identifieur interne : 000859 ( Main/Exploration ); précédent : 000858; suivant : 000860Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus
Auteurs : Nargis Aman [Pakistan] ; Khalid Rauf [Pakistan] ; Shujaat Ali Khan [Pakistan] ; Ahmed Tokhi [Pakistan] ; Naeem-Ur Rehman [Pakistan] ; Muhammad Arfat Yameen [Pakistan]Source :
- International Journal of Nanomedicine [ 1176-9114 ] ; 2019.
Abstract
Url:
DOI: 10.2147/IJN.S202256
PubMed: 31118625
PubMed Central: 6503187
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus</title><author><name sortKey="Aman, Nargis" sort="Aman, Nargis" uniqKey="Aman N" first="Nargis" last="Aman">Nargis Aman</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rauf, Khalid" sort="Rauf, Khalid" uniqKey="Rauf K" first="Khalid" last="Rauf">Khalid Rauf</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Shujaat Ali" sort="Khan, Shujaat Ali" uniqKey="Khan S" first="Shujaat Ali" last="Khan">Shujaat Ali Khan</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tokhi, Ahmed" sort="Tokhi, Ahmed" uniqKey="Tokhi A" first="Ahmed" last="Tokhi">Ahmed Tokhi</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rehman, Naeem Ur" sort="Rehman, Naeem Ur" uniqKey="Rehman N" first="Naeem-Ur" last="Rehman">Naeem-Ur Rehman</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yameen, Muhammad Arfat" sort="Yameen, Muhammad Arfat" uniqKey="Yameen M" first="Muhammad Arfat" last="Yameen">Muhammad Arfat Yameen</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31118625</idno><idno type="pmc">6503187</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6503187</idno><idno type="RBID">PMC:6503187</idno><idno type="doi">10.2147/IJN.S202256</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000629</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000629</idno><idno type="wicri:Area/Pmc/Curation">000629</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000629</idno><idno type="wicri:Area/Pmc/Checkpoint">000800</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000800</idno><idno type="wicri:Area/Ncbi/Merge">000641</idno><idno type="wicri:Area/Ncbi/Curation">000641</idno><idno type="wicri:Area/Ncbi/Checkpoint">000641</idno><idno type="wicri:doubleKey">1176-9114:2019:Aman N:effect:of:commercial</idno><idno type="wicri:Area/Main/Merge">000859</idno><idno type="wicri:Area/Main/Curation">000859</idno><idno type="wicri:Area/Main/Exploration">000859</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of commercial and green synthesized ZnO NPs in murine model of chloroquine-induced pruritus</title><author><name sortKey="Aman, Nargis" sort="Aman, Nargis" uniqKey="Aman N" first="Nargis" last="Aman">Nargis Aman</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rauf, Khalid" sort="Rauf, Khalid" uniqKey="Rauf K" first="Khalid" last="Rauf">Khalid Rauf</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Khan, Shujaat Ali" sort="Khan, Shujaat Ali" uniqKey="Khan S" first="Shujaat Ali" last="Khan">Shujaat Ali Khan</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tokhi, Ahmed" sort="Tokhi, Ahmed" uniqKey="Tokhi A" first="Ahmed" last="Tokhi">Ahmed Tokhi</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rehman, Naeem Ur" sort="Rehman, Naeem Ur" uniqKey="Rehman N" first="Naeem-Ur" last="Rehman">Naeem-Ur Rehman</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yameen, Muhammad Arfat" sort="Yameen, Muhammad Arfat" uniqKey="Yameen M" first="Muhammad Arfat" last="Yameen">Muhammad Arfat Yameen</name><affiliation wicri:level="1"><nlm:aff id="AFF0001"><institution>Department of Pharmacy COMSATS University Islamabad, Abbottabad Campus</institution>,<addr-line>Abbottabad</addr-line>,<addr-line>KPK</addr-line>,<country>Pakistan</country></nlm:aff><country xml:lang="fr">Pakistan</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">International Journal of Nanomedicine</title><idno type="ISSN">1176-9114</idno><idno type="eISSN">1178-2013</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Purpose:</bold> To investigate the effects of zinc oxide nanoparticles (ZnO NPs) on chloroquine (CQ)-induced itching, and overall behavior of mice after oral administration of ZnO NPs of various sizes and doses.</p><p><bold>Background:</bold> With the wide-spread use of ZnO NPs in pharmaceuticals and cosmetics, concerns about their safety and toxicity are also increasing. Multiple aspects of ZnO NPs regarding cytotoxicity and tolerability are under investigation globally. Still, a clear conclusion about their safety has not been reached. Chloroquine phosphate is an antimalarial with known side effects of itching in humans and animals. In this study, CQ was used to induce itching in mice, and the effects of ZnO NPs on scratching and other neurological behavior of mice were observed.</p><p><bold>Methods:</bold> Female BALB/c mice were divided into eleven groups of six mice each. ZnO NPs of various sizes and doses were administered orally 1 hour before CQ (32 mg/kg body weight) was administered subcutaneously. The effect of ZnO NPs on CQ-induced pruritus was observed for the next 30 minutes. Simultaneously, overall behavioral changes (socialization and locomotion) were also recorded using a video camera.</p><p><bold>Results:</bold> A significant reduction (<italic>P</italic>˂0.001) in scratching bouts was observed at all three doses of ZnO NPs (particle sizes 100, 30 nm, and green synthesized 30 nm). Locomotion was reduced significantly (<italic>P</italic>˂0.001) in ZnO NPs-treated groups in comparison to normal saline and CQ group, additionally, a significant increase in socialization (<italic>P</italic>˂0.05) was observed in ZnO NP-treated groups as compared to CQ group.</p><p><bold>Conclusion:</bold> ZnO NPs, instead of aggravating the dermatological condition, ameliorated the pruritus. All sizes of ZnO NPs used significantly improved socialization among mice and reduced locomotion activity.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Pakistan</li></country></list><tree><country name="Pakistan"><noRegion><name sortKey="Aman, Nargis" sort="Aman, Nargis" uniqKey="Aman N" first="Nargis" last="Aman">Nargis Aman</name></noRegion><name sortKey="Khan, Shujaat Ali" sort="Khan, Shujaat Ali" uniqKey="Khan S" first="Shujaat Ali" last="Khan">Shujaat Ali Khan</name><name sortKey="Rauf, Khalid" sort="Rauf, Khalid" uniqKey="Rauf K" first="Khalid" last="Rauf">Khalid Rauf</name><name sortKey="Rehman, Naeem Ur" sort="Rehman, Naeem Ur" uniqKey="Rehman N" first="Naeem-Ur" last="Rehman">Naeem-Ur Rehman</name><name sortKey="Tokhi, Ahmed" sort="Tokhi, Ahmed" uniqKey="Tokhi A" first="Ahmed" last="Tokhi">Ahmed Tokhi</name><name sortKey="Yameen, Muhammad Arfat" sort="Yameen, Muhammad Arfat" uniqKey="Yameen M" first="Muhammad Arfat" last="Yameen">Muhammad Arfat Yameen</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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